Colleges Expect Lower Enrollment





An annual survey of colleges and universities found that a growing number of schools face declining enrollment and less revenue from tuition.




The survey, released by the credit ratings agency Moody’s Investors Service on Thursday, found that nearly half of colleges and universities that responded expected enrollment declines for full-time students, and a third of the schools expected tuition revenue to decline or to grow at less than the rate of inflation.


“The cumulative effects of years of depressed family income and net worth, as well as uncertain job prospects for many recent graduates, are combining to soften student market demand at current tuition prices,” Emily Schwarz, a Moody’s analyst and lead author of the report, said in a statement.


The growing financial challenges for colleges and universities come as students and graduates have amassed more than $1 trillion in student debt, and many are struggling to pay their bills. Nearly one in six people with an outstanding federal student loan balance is in default, the federal government says.


Before the financial crisis of 2008, colleges and universities routinely raised tuition with little effect on the number of prospective students who applied. Some private colleges said that applications actually rose when they increased prices, apparently because families equated higher prices with quality.


But that attitude has changed, in part because family incomes have declined. Ms. Schwarz also noted, “Tougher governmental scrutiny of higher education costs and disclosure practices is adding regulatory and political pressure to tuition and revenue from rising at past rates.”


In addition, she noted that budget negotiations in Congress could lead to cuts in student aid programs while the share of students that depend on government help continued to rise. At public universities, federal loans finance a median of 40 percent of student charges; at private schools, the median is 21 percent.


While nearly half the schools that responded to the survey expected enrollment declines, the changes are expected to be minimal and overall enrollment should remain relatively flat. The enrollment declines are more pronounced among graduate programs; small, lower-rated universities; and public schools in the Northeast and Midwest, where the number of high school seniors is declining.


By comparison, about 15 percent of the schools that responded to the survey in the fall of 2010 reported enrollment declines.


Daniel J. Hurley, director of state relations and policy analysis at the American Association of State Colleges and Universities, said he was not surprised by the findings. He said that after years of cuts, he expected an uptick in state financing for public colleges and universities in the coming year.


In addition, he said states had become more strategic in how they finance higher education, offering incentives for schools that provide more graduates in critical fields, like engineering.


Tony Pals, spokesman for the National Association of Independent Colleges and Universities, which represents nonprofit private schools, said the report confirmed the tough realities of higher education. “Economic, demographic, marketplace and technological trends are converging to cause an unprecedented time of change for higher education. The new reality is that colleges are expecting to have to do more with less for years to come,” he said in an e-mail.


But Mr. Pals noted that his members had a history of resiliency and innovation. “We are seeing a jump in three-year bachelor’s degree programs, so-called no-frills satellite campuses and academic partnerships between four-year private colleges and local community colleges.”


Over all, 18 percent of private universities and 15 percent of public schools in the survey projected a decline in net tuition revenue for fiscal 2013. A much larger share, one-third, said net tuition revenue would decline or grow by less than 2 percent.


“Such weak revenue growth often means a college cannot afford salary increases or new program investments unless it cuts spending on staff and existing programs,” the Moody’s report said. By comparison, in fiscal 2008, only 11 percent of private schools and 9 percent of public schools did not increase tuition revenue by 2 percent or more.


Since the financial crisis, tuition at public schools has grown more rapidly than private ones, largely to offset sharp costs in state financing. Public universities have responded by recruiting more out-of-state and international students, who can pay more than in-state students.


Private schools have provided more and more financial aid to students to offset their higher price, a trend that many view as unsustainable.


Moody’s has a more upbeat view of the most elite private schools and flagship public universities, which continue to have strong student demand and, in many instances, many other sources of revenue.


The Moody’s survey included 165 nonprofit private universities and 127 four-year public universities.


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A Tale of 2 Strategies: The Twitter Genius of Chuck Grassley and Cory Booker






If you’re on Twitter and not following Sen. Chuck Grassley, you’re not using Twitter correctly.


The Iowa Republican is known for his colorful and personal Twitter feed. Take a gander: He personally tweets about everything from the History Channel to “Obamacare” to an incident in which he hit a deer with his car  (“assume dead”). Grassley’s tweets take us along for a ride, one that’s often riddled with spelling errors (which he has said is due to his distaste for typing and the iPhone’s auto-correct function).







Pres/Cong need 2work on Wash spending prob. No time 2waste b/4 Mar. Pres promised tax hike is done. Now he needs 2keep promise 4 less spend


— ChuckGrassley (@ChuckGrassley) January 4, 2013



Rained inIowa this weekend. Still 8 inches shortIowa still still listed dangerous drought pray For rain


— ChuckGrassley (@ChuckGrassley) December 17, 2012



Fred and I hit a deer on hiway 136 south of Dyersville. After I pulled fender rubbing on tire we continued to farm. Assume deer dead


— ChuckGrassley (@ChuckGrassley) October 26, 2012


Contrast Grassley’s tweets to another lawmaker known for his active and personal feed: Newark, N.J., Mayor Cory Booker. On Twitter, he’s part mayor, part celebrity. Booker tweets about city services and was widely praised for how he utilized the platform in the aftermath of superstorm Sandy to connect directly with residents. But then he’ll retweet someone who says she’s going to get a Cory Booker quote tattoo or someone who has a “political crush” on him. Sometimes, Booker tweets like a Kardashian.



Think so, call 9737334311. My people will tell u RT @hennybottle: Is the number to get downed wires removed same for all of essex county?


— Cory Booker (@CoryBooker) January 8, 2013



“Hey, Never Met U, Your tweet’s Crazy, I’ll DM My Number, So Call Me Maybe?” MT @ann_ralston: I have a non-sexual, political crush on you!


— Cory Booker (@CoryBooker) January 8, 2013



Wow. An honor I never quite imagined RT @rachelanncohen: deliberating between several Cory Booker quotes for my next tattoo.


— Cory Booker (@CoryBooker) January 8, 2013



I love you too! RT @alwoldegorgeous: I can actually say I am in love with @kimkardashian#girlcrush


— Kim Kardashian (@KimKardashian) December 12, 2012


Obviously, Booker is savvier with Twitter than Grassley, and he’s utilized the platform effectively, as he vies for statewide office. Booker’s a PR genius with social media. Grassley’s himself–typos, rants, and all. So while Booker probably doesn’t need to take Twitter lessons from the six-term senator, there’s something decidedly old school and earnest that’s kind of appealing about Grassley’s feed, something that would be nice to see in Booker’s feed, too.



Welcome to Twitter Pope Benedict. U will find it useful and interesting


— ChuckGrassley (@ChuckGrassley) December 3, 2012


CORRECTION: Grassley has served in the Senate for six terms.  An earlier version of the story incorrectly listed his tenure.


Social Media News Headlines – Yahoo! News





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Warner wins legal victory for control of Superman


SAN FRANCISCO (AP) — Just in time for the summer release of a hoped-for blockbuster movie "Man of Steel," Warner Bros. won a second significant legal victory Thursday giving it complete commercial control of the lucrative Superman franchise.


A three-judge panel of the 9th U.S. Circuit of Appeals unanimously ruled that the heirs of Superman's co-creator Jerome Siegel must abide by a 2001 letter written by the family's attorney accepting Warner Bros.' offer for their 50 percent share of Superman. Though the five-page letter was never formalized into a contract, the appeals court said it was still binding.


"Statements from the attorneys for both parties establish that the parties had undertaken years of negotiations, that they had resolved the last outstanding point in the deal during a conversation on Oct. 15, 2001, and that the letter accurately reflected the material terms they had orally agreed to on that day," Judge Stephen Reinhardt wrote for the panel.


The ruling Thursday undoes a 2008 trial court decision ordering Warner Bros. to share an undetermined amount of money earned since 1999 with the heirs, and to give the family control of key components of the Superman story, including his costume. If that decision were to stand, the studio would have had to negotiate a new costly royalty agreement with the family.


"The court's decision paves the way for the Siegel finally to receive the compensation they negotiated for and which DC has been prepared to pay for over a decade," Warner Bros. said in a prepared statement, referring to its DC Comics division. "We are extremely pleased that Superman's adventures can continue to be enjoyed across all media platforms worldwide for generations to come."


The family's attorney, Marc Toberoff, didn't respond to a request for comment.


Toberoff said earlier that he would appeal another significant Warner Bros. victory won in October involving the family of Superman's other creator, Joseph Shuster, and their bid for half the commercial rights. Toberoff also represents the Shuster heirs, who lost their bid to retain a 50 percent share of Superman.


A federal judge in Los Angeles had ruled that Shuster's sister and brother relinquished any chance to reclaim Superman copyrights in exchange for annual pension payments from DC Comics. U.S. District Judge Otis Wright noted in that case that the families of both creators have been paid in excess of $4 million since 1978, plus undefined bonuses and medical benefits.


In April, the $412 check that DC Comics wrote in 1938 to acquire Superman and other creative works by Shuster and Siegel sold for $160,000 in an online auction.


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Children’s Flu Medicine in Short Supply





As influenza cases surge around the country, health officials say they are trying to stem a shortage of treatments for children.




Pharmacies around the country have reported dwindling supplies of liquid Tamiflu, a prescription flu medicine that can ease symptoms if taken within 48 hours of their onset. The drug is available in capsules for adults and a liquid suspension for children and infants.


“There are intermittent shortages of the liquid version (but not the capsule version) due to the supplier’s challenges to meet the current demand,” Carolyn Castel, a spokeswomen for CVS Caremark, said in an e-mail.


Pharmacies around the country are experiencing shortages of the liquid suspension “due to recent increased demand,” Sarah Clark-Lynn, a spokeswoman for the Food and Drug Administration, said on Thursday.


Ms. Clark-Lynn said the F.D.A. was working with the company that markets Tamiflu, Genentech, to increase supplies. The agency is also letting pharmacists know that in emergencies they can compound the adult Tamiflu capsules to make liquid versions for children.


A similar shortage of Tamiflu has hit Canada, which has also been gripped by widespread flu outbreaks, prompting the government there to tap into a national stockpile of the drug.


“That really unexpected increase in demand — far above other influenza seasons — has really depleted the usual stocks which in any other season would have been more than sufficient,” Dr. Barbara Raymond, director of pandemic preparedness for the Public Health Agency of Canada, told The Ottawa Citizen.


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2 Years Into Nokia Turnaround, Some Good News





Nearly two years ago, Stephen A. Elop, Nokia’s new chief executive, spoke of flaming ocean platforms and shark-infested waters to describe the problems he inherited as the company teetered on the brink of irrelevance.




Mr. Elop painted the bleak outlook as he prescribed a radical cure for the Finnish mobile phone pioneer: The rejection of the company’s own Symbian smartphone operating system for a shotgun wedding to Microsoft, itself stumbling badly with smartphone software. After that, sales slumped sharply, losses mounted and huge layoffs followed.


On Thursday, he delivered unexpected good news: a profit. Sales of its new smartphone line, the Lumia, powered by Microsoft’s Windows Phone operating system, soared more than 50 percent in the fourth quarter of last year, according to preliminary financial information.


In what was seen as a make-or-break quarter, Mr. Elop said Nokia would break even or turn a 2 percent profit rather than report a loss as large as 10 percent, as analysts expected.


Nokia will report its earnings on Jan. 24.


Wall Street reacted to the announcement by sending Nokia’s American depositary receipts up 18.67 percent, or 70 cents, to $4.45.


“While we definitely experienced some tough challenges in the first half of 2012, we are managing through these issues,” Mr. Elop said in a conference call with journalists.


What Nokia has accomplished under Mr. Elop is to produce a line of increasingly competitive smartphones that are starting to draw favorable comparisons with those from Samsung and Apple, the two companies most responsible for knocking Nokia from its lofty perch.


“The Lumia smartphones are night-and-day different from Nokia’s old Symbian handsets,” said Francisco Jeronimo, an analyst with the International Data Corporation in London. “I think what we are starting to see now is what will be a steady turnaround in Nokia’s fortunes.”


The company, which dominated the cellphone business until Apple introduced its iPhone in 2007, still has a long way to go to achieve its former stature. In the third quarter, Nokia held on to a 4 percent share of the global smartphone market, and was ranked a distant No. 10 in the sector, according to Strategy Analytics, a research firm.


Samsung and Apple, the No. 1 and No. 2 smartphone makers, together had 50 percent of the global smartphone market, and their sales were growing. While its competitors rose, Nokia has generated nearly 5 billion euros ($6.5 billion) in losses under Mr. Elop, and eliminated a third of its work force.


The key to its turnaround was the introduction in October of the top-of-the-line Lumia 920 and 820, which used the new Windows Phone 8 operating system. Since then, Nokia has spent heavily on advertising in Britain and Europe to promote the models. The company will not disclose how much it had spent on its campaign, but its television ads were ubiquitous over the holidays, said Neil Mawston, an analyst at Strategy Analytics in London.


The heavy promotion, which was aided by Microsoft’s own advertising, has helped the company recapture some of its lost glory, Mr. Mawston said.


But he warned that “Nokia still lacks the true killer phone that will enable it to compete with the iPhone 5 or Samsung Galaxy S III.” He expected Nokia’s share of the global smartphone market to rise to 6 percent by the end of the year.


The company’s financial position is likely to revive even more quickly as a result of the strict cost-cutting imposed by Mr. Elop, who ran Microsoft’s business software division before joining Nokia in late 2010.


Since then, Nokia has shut factories across Europe. Last month, the company sold its 540,000-square-foot glass-and-wood headquarters in the Helsinki suburb of Espoo to Finnish investors, and leased it back. The maneuver netted Nokia 170 million euros.


Besides a more competitive array of phones, Nokia has discarded its market-leader mentality. Employees are now routinely traveling in economy class and sharing rides to airports. Workers no longer use costly telephone conference calling but speak in group teleconferences using less expensive Internet calling services.


“The company is a lot smaller now but people are working better together,” said Susan Sheehan, a Nokia spokeswoman. “Everyone has been pitching in.”


Even at Nokia Siemens, the company’s long-suffering network equipment venture, the future is looking brighter than it was two years ago. On Thursday, Nokia said the unit, which contributes about 40 percent of total sales, would report an operating profit for the quarter, its third consecutive quarterly profit.


Nokia, in its announcement to investors, even revised the operating profit margin forecast at the venture to 13 to 15 percent of sales, up from a range of 4 to 12 percent.


Looking ahead, Nokia said it expected to return to an operating loss of 2 percent of sales because of the first-quarter postholiday buying lull and fierce competition. But the results for the coming three months could vary widely.


Pete Cunningham, an analyst at Canalys, a research firm in Reading, England, said that Nokia still faced challenges. “2013 could still turn out to be another very difficult year for Nokia. It is way too premature to say that the company has made a turnaround.”


Mr. Cunningham said he used the Lumia 920, Nokia’s newest smartphone, during the Christmas holidays and liked it.


“But the more I used the phone, the more apparent it became to me that there are big gaps between Lumia and its competitors in terms of the functionality and usability of its apps,” Mr. Cunningham said.


“I still think there is a lot of work to be done on Lumia.”


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High Hay Prices Encourage More Thefts From Farms


Matthew Staver for The New York Times


Conrad Swanson has had bales of hay stolen from his field in Wellington, Colo.







DENVER _ Across the heartland, ranchers, farmers and county sheriffs are grappling with a new scourge: hay rustling.




Months of punishing drought and grass fires have pushed the price of hay, grain and other animal feed to near records, making the golden bales an increasingly irresistible target for thieves. Some steal them for profit. Others are fellow farmers acting out of desperation, their fields too brown to graze animals and their finances too wrecked to afford enough feed for their cattle.


“It’s the economics of the times,” said Jack McGrath, the undersheriff in Colorado’s Weld County, where hay thefts rose to 15 last year from 7 in 2011.


At Mark Reifenrath’s farm in northern Colorado, the thieves struck at night. Two men driving a stolen pickup opened an unguarded farm gate by the side of the road, rolled into Mr. Reifenrath’s alfalfa field and headed toward their quarry: 800-pound square bundles of freshly cut hay.


They set to work that October night, hefting two bales onto a flatbed trailer. They might have gotten more, but an employee happened by and noticed flashlight beams bouncing around in the darkness. Something was up. He yelled out, and the men disappeared into a patch of cattails, leaving behind a half-loaded trailer.


“Maybe it’s not the crime of the century, but it affects us,” Mr. Reifenrath said.


Sheriffs in rural counties in Colorado, Oklahoma, Nebraska and Kansas say the spike in hay thefts is part of a broader rise in agricultural crime.


California’s farmers have grappled recently with growing thefts of grapes, beehives and avocados, and sheriffs say high prices of scrap metal have made agricultural machinery — whether it works or not — an appealing target. Dubious online merchants are selling feed to farmers but never delivering. On the range, wire fences are being clipped to allow interloping herds to poach grazing land.


Most thieves make off with less than a ton of hay — about $200 to $300 worth, depending on the quality. But on Labor Day in Wellington, Colo., thieves hot-wired a front-end loader and stole enough hay from Conrad T. Swanson’s ranch to fill the flatbed trailer of a semi.


“It’s not like someone was just driving by and took enough to feed a horse,” Mr. Swanson said.


Law enforcement officials said they could do little to prevent the thefts or catch the culprits. Most of the hay is nipped at night along remote roads, from fields and barns hundreds of yards from the nearest home. Because one bundle of hay tends to look like every other one, once a bale is stolen, reclaiming it is harder than finding a needle in a — well, never mind.


To ward off the hay thieves, farmers are padlocking their gates and painting their bales with their brands. Some are splicing their hay with ribbons that mark their ownership.


In Tillman County, Okla., hay thefts became so rampant that Sheriff Bobby Whittington decided to lay a trap. He bugged a bale in a particularly theft-prone field with a GPS unit and set to waiting, sure that thieves would strike. Sure enough, his phone rang one night last March with the news that the tracking device was on the move.


The sheriff hopped into his car and headed toward the signal. When he reached it, he found his culprits, and the bugged bale. Pulling them over, he said, he told the driver, “We need to talk about that hay bale you’ve got there.”


The men were belligerent at first, Mr. Whittington said, until he explained how he had tracked them down. Before being arrested, the driver offered a plea.


“He just hung his old head and said, ‘Can I take it back?’” Mr. Whittington said. “And I said, ‘No.’”


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Go Ahead, Keep Being Mean to Celebrities on Twitter






We realize there’s only so much time one can spend in a day watching new trailers, viral video clips, and shaky cell phone footage of people arguing on live television. This is why every day The Atlantic Wire highlights the videos that truly earn your five minutes (or less) of attention. Today:  


RELATED: The Honey Boo Boo Nature Special; Everyone’s Favorite Sleepwalking Mom






We usually don’t condone being an impolite jerk to anyone, especially on social media. But we kind of make an exception because, well, if everyone was nice to everyone all of a sudden, we’d run out of fun Jimmy Kimmel segments where celebrities read their tweets:


RELATED: Ai Weiwei’s ‘Gangnam Style’ Isn’t Bad


RELATED: So Which Boyfriend Is Taylor Swift Singing About Now?


Oh man, this giant squid is like the most famous sea creature celebrity of the moment. And yes, it’s way freakier in motion:


RELATED: Katie Holmes Goes Bust on Broadway


RELATED: Justin Bieber is Coming to Town


So fine, this is sort of bending the rules per se because this isn’t really a video-video. It’s the Game of Thrones introduction with beatboxing by the Stark children. 


And finally, here is one minute of a man singing all the songs involving the word “baby.” And in case you were wondering, yes, Justin Bieber is officially in the Baby Pantheon of Music. 


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Adele to make post-baby debut at Golden Globes


BEVERLY HILLS, Calif. (AP) — Adele is coming to the Golden Globes.


The executive producer of the show says the 24-year-old Grammy-winning pop star is set to make her first post-baby appearance at Sunday's ceremony, where she is nominated for original song for the James Bond theme "Skyfall."


Adele welcomed her first child, with boyfriend Simon Konecki, in October. The singer has kept a low profile since announcing her pregnancy in June after sweeping the Grammy Awards last February with six wins.


Her single, "Skyfall," will compete at the Golden Globes with Taylor Swift's song from "The Hunger Games," Jon Bon Jovi's number from "Stand Up Guys," Keith Urban's track from "Act of Valor," and "Suddenly" from "Les Miserables."


The Globes will be presented Sunday at the Beverly Hilton Hotel.


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Pap Test May Prove Useful at Detecting More Types of Cancer, Study Suggests





The Pap test, which has prevented countless deaths from cervical cancer, may eventually help to detect cancers of the uterus and ovaries as well, a new study suggests.




For the first time, researchers have found genetic material from uterine or ovarian cancers in Pap smears, meaning that it may become possible to detect three diseases with just one routine test.


But the research is early, years away from being used in medical practice, and there are caveats. The women studied were already known to have cancer, and while the Pap test found 100 percent of the uterine cancers, it detected only 41 percent of the ovarian cancers. And the approach has not yet been tried in women who appear healthy, to determine whether it can find early signs of uterine or ovarian cancer.


On the other hand, even a 41 percent detection rate would be better than the status quo in ovarian cancer, particularly if the detection extends to early stages. The disease is usually advanced by the time it is found, and survival rates are poor. About 22,280 new cases were expected in the United States in 2012, and 15,500 deaths. Improved tests are urgently needed.


Uterine cancer has a better prognosis, but still kills around 8,000 women a year in the United States.


These innovative applications of the Pap test are part of a new era in which advances in genetics are being applied to the detection of a wide variety of cancers or precancerous conditions. Scientists are learning to find minute bits of mutant DNA in tissue samples or bodily fluids that may signal the presence of hidden or incipient cancers.


Ideally, the new techniques would find the abnormalities early enough to cure the disease or even prevent it entirely. But it is too soon to tell.


“Is this the harbinger of things to come? I would answer yes,” said Dr. Bert Vogelstein, director of the Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins University, and a senior author of a report on the Pap test study published on Wednesday in the journal Science Translational Medicine. He said the genomes of more than 50 types of tumors had been sequenced, and researchers were trying to take advantage of the information.


Similar studies are under way or are being considered to look for mutant DNA in blood, stool, urine and sputum, both to detect cancer and also to monitor the response to treatment in people known to have the disease.


But researchers warn that such tests, used for screening, can be a double-edged sword if they give false positive results that send patients down a rabbit hole of invasive tests and needless treatments. Even a test that finds only real cancers may be unable to tell aggressive, dangerous ones apart from indolent ones that might never do any harm, leaving patients to decide whether to watch and wait or to go through surgery, chemotherapy and radiation with all the associated risks and side effects.


“Will they start recovering mutations that are not cancer-related?” asked Dr. Christopher P. Crum, a professor at Harvard Medical School who was not involved in the research.


But he also called the study a “great proof of principle,” and said, “Any whisper of hope to women who suffer from endometrial or ovarian cancer would be most welcome.”


DNA testing is already performed on samples from Pap tests, to look for the human papillomavirus, or HPV, which causes cervical cancer. Dr. Vogelstein and his team decided to try DNA testing for cancer. They theorized that cells or DNA shed from cancers of the ovaries and the uterine lining, or endometrium, might reach the cervix and turn up in Pap smears.


The team picked common mutations found in these cancers, and looked for them in tumor samples from 24 women with endometrial cancer and 22 with ovarian cancer. All the cancers had one or more of the common mutations.


Then, the researchers performed Pap tests on the same women, and looked for the same DNA mutations in the Pap specimens. They found the mutations in 100 percent of the women with endometrial cancer, but in only 9 of the 22 with ovarian cancer. The test identified two of the four ovarian cancers that had been diagnosed at an early stage.


Finally, the team developed a test that would look simultaneously for cancer-associated mutations in 12 different genes in Pap samples. Used in a control sample of 14 healthy women, the test found no mutations — meaning no false-positive results.


Dr. Luis A. Diaz, the other senior author of the report and an associate professor of oncology at Johns Hopkins, called the research a step toward a screening test that at first blush appears very effective at detecting endometrial cancer, though obviously less so at finding ovarian cancer.


“Probably one of the most exciting features of this approach,” Dr. Diaz said, “is that we wanted a test that would seamlessly integrate with routine medical practice that could be utilized with the same test that women get every day all over the world, the Pap smear.”


But, he added: “We can’t say it’s ready for prime time. Like all good science, it needs to be validated.”


He and other members of the team said it might be possible to improve the detection rate for ovarian cancer by looking for more mutations and by changing the technique of performing Pap tests to increase the likelihood of capturing cells from the ovary. The change might involve timing the test to a certain point in a woman’s monthly cycle, using a longer brush to collect cells from deeper within the cervix or prescribing a drug that would raise the odds of cells being shed from the ovary.


The technique also needs to be tested in much larger groups of women, including healthy ones, to find out whether it works, particularly at finding cancers early enough to improve survival. And studies must also find out whether it generates false positive results, or identifies cancers that might not actually need to be treated.


Michael H. Melner, a program director in molecular genetics and biochemistry for the American Cancer Society, called the research “very promising,” in part because it is based on finding mutations.


“It tells you not just that cancer is there, but which mutation is there,” Dr. Melner said. “As we learn more and more about which mutations are associated with more or less severe forms of cancer, it’s more information, and possibly more diagnostic.”


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James M. Buchanan, Economic Scholar, Dies at 93


James M. Buchanan, a scholar and author whose analyses of economic and political decision-making won the 1986 Nobel in economic sciences and shaped a generation of conservative thinking about deficits, taxes and the size of government, died on Wednesday in Blacksburg, Va. He was 93.


Alex Tabarrok, the director of the Center for Study of Public Choice at George Mason University, which Mr. Buchanan founded, confirmed his death.


Dr. Buchanan, a professor emeritus at George Mason, in Fairfax, Va., was a leading proponent of public choice theory, which assumes that politicians and government officials, like everyone else, are motivated by self-interest — getting re-elected or gaining more power — and do not necessarily act in the public interest.


He argued that their actions could be analyzed, and even predicted, by applying the tools of economics to political science in ways that yield insights into the tendencies of governments to grow, increase spending, borrow money, run large deficits and let regulations proliferate.


The logic of self-interest was nothing new. Machiavelli’s 16th-century treatise “The Prince” detailed cynical rules of statecraft to extend political power. Thomas Hobbes, in his 17th-century book “Leviathan,” held that aggressive, self-serving acts were “natural” unless forbidden by law. Adam Smith’s “The Wealth of Nations,” published in 1776, noted that people pursuing their own good also produced benefits for society at large.


But Dr. Buchanan contended that the pursuit of self-interest by modern politicians often led to harmful public results. Courting voters at election time, for example, legislators will approve tax cuts and spending increases for projects and entitlements favored by the electorate. This combination can lead to ever-rising deficits, public debt burdens and increasingly large governments to conduct the public’s business.


Indeed, he said, governments had grown so vast and complex that it was no longer possible for elected officials to make more than a fraction of the policy decisions that genuinely affect the people. Thus, he said, much discretionary power is actually held by civil functionaries who can manipulate priorities, impose barriers to entitlements and pressure legislators for rules and budgets favorable to their own interests.


Dr. Buchanan did not invent the theory of public choice, an idea whose origins are obscure but that arose in modern economics literature in the late 1940s. But from the 1950s onward, he became its leading proponent, spearheading a group of economists in Virginia that sought to change the nature of the political process, to bring it more into line with what the group considered the wishes of most Americans.


In lectures, articles and more than 30 books, Dr. Buchanan amplified on the theory of public choice and argued for smaller government, lower deficits and fewer regulations — a spectrum of policy objectives that were ascendant in the 1980s conservative agenda of President Ronald Reagan.


Over the years since Dr. Buchanan won the Nobel, much of what he predicted has played out. Government is bigger than ever. Tax revenue has fallen far short of public programs’ needs. Public and private borrowing has become a way of life. Politicians still act in their own interests while espousing the public good, and national deficits have soared into the trillions.


Dr. Buchanan partly blamed Keynesian economics for what he considered a decline in America’s fiscal discipline. John Maynard Keynes argued that budget deficits were not only unavoidable but in fiscal emergencies were even desirable as a means to increase spending, create jobs and cut unemployment. But that reasoning allowed politicians to rationalize deficits under many circumstances and over long periods, Dr. Buchanan contended.


In a commentary in The New York Times in March 2011, Tyler Cowen, an economics professor at George Mason, said his colleague Dr. Buchanan had accurately forecast that deficit spending for short-term gains would evolve into “a permanent disconnect” between government outlays and revenue.


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